abstract：PURPOSE OF REVIEW:The mortality and morbidity associated with severe acute malnutrition (SAM) remain high. A summary of recent studies that are of interest to clinicians treating children with SAM is provided. RECENT FINDINGS:Three important themes emerged in 2015: the use of anthropometry in the diagnosis of SAM and ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Nel ED

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This article describes recent findings regarding lipid metabolism in critical illness as well as in lipid therapy. RECENT FINDINGS:In critical illness, in the presence of a decrease in lipid absorption, adipose tissue lipolysis raises triglyceride levels. High-density lipoprotein and low-density lipo...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Green P,Theilla M,Singer P

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Preventing unintentional weight and muscle loss is of crucial importance to maintain the condition and well-being of patients with cancer, improve treatment response and tolerance, and prolong survival. Anabolic resistance might explain why some cancer patients do not respond to nutritional interventi...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Engelen MP,van der Meij BS,Deutz NE

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The obesity paradox is a highly controversial concept that may be attributed to methodological limitations related to its identification. One of the primary concerns is the use of BMI to define obesity. This index does not differentiate lean versus adipose tissue compartments (i.e. body composition) c...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Prado CM,Gonzalez MC,Heymsfield SB

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:There is increasing clinical and pathophysiological evidence that a premature aging process is involved in the pathogenesis of systemic complications of many chronic organ diseases, which result in analogous phenotypes, including premature vascular aging, osteoporosis and muscle wasting. Novel develop...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Kooman JP,Shiels PG,Stenvinkel P

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review describes some of the advances made over the past year in NMR-based metabolomics for the elucidation of known and unknown compounds, including new ways of how to combine this information with high-resolution mass spectrometry. RECENT FINDINGS:A new method allows the back-calculation of ma...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Bingol K,Brüschweiler R

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Epigenetics has emerged in recent years as one of the most important biological mechanisms linking exposures across the life course to long-term health. This article reviews recent developments in our understanding of the metabolic and genetic determinants of epigenetic variation in human populations....

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Haggarty P

更新日期：2015-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Overweight and obesity represent a significant health burden during pregnancy, placing women and their infants at increased risk of adverse health outcomes. Although there is considerable observational literature describing the effect of gestational weight gain in pregnancy, research efforts have focu...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Dodd JM,O'Brien CM,Grivell RM

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The main aim of this review is to summarize current knowledge of tumor protein p53-inducible nuclear protein 2 (TP53INP2) function and its role in skeletal muscle proteostasis. RECENT FINDINGS:Autophagy is directly involved in the regulation of skeletal muscle mass. Thus, excessive autophagy is assoc...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Sala D,Zorzano A

更新日期：2015-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight the recent evicence for optimal protein intake and protein supplementation in older adults. A special focus has been placed on the effects on muscle protein synthesis, strength and overall performance in this population. RECENT FINDINGS:Although for older adults, some additional evidence...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Bauer JM,Diekmann R

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the recent work examining the importance of taurine in skeletal muscle and outline the discrepancy that exists between research findings in rodent vs. human skeletal muscle. RECENT FINDINGS:There is clear evidence that a normal taurine level is important for the normal functioning of skele...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Spriet LL,Whitfield J

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Vitamin K is an enzyme cofactor for the carboxylation of vitamin K-dependent proteins. Functions include coagulation and regulation of calcification. Different clinical conditions may alter vitamin K requirements by affecting vitamin K status and vitamin K-dependent proteins carboxylation that are rev...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Harshman SG,Saltzman E,Booth SL

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To understand the interest of functional food in low-income countries by analyzing various necessary factors. RECENT FINDINGS:Being on a low income would appear to relate most often to an unbalanced diet, both qualitatively and quantitatively, which may be damaging to health in the long term. Most ch...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Das A,Chakraborty R

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Skeletal muscle and lean body mass may be vital to prognosis and functional recovery in chronic and acute illness, particularly in conditions in which muscle atrophy is prevalent. Ultrasound provides a precise and expedient method to measure muscle mass and changes in skeletal muscle at the bedside. ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Mourtzakis M,Wischmeyer P

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:New evidence has recently supported the notion that brown adipose tissue (BAT) is present in adult humans and can play a prominent role in the regulation of body weight and metabolism. This has renewed the efforts to understand the physiologic mechanisms by which BAT is activated, which in turn could ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Loyd C,Obici S

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Autophagy is an evolutionarily conserved cellular programme for the turnover of organelles, proteins, and other macromolecules, involving the lysosomal degradation pathway. Emerging evidence suggests that autophagy can play a central role in human metabolism as well as impact diverse cellular processe...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Ryter SW,Koo JK,Choi AM

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Food allergy affects up to 10% of preschool children, and continues to increase in prevalence in many countries, resulting in a major public health issue, with practical implications for the food industry, educational establishments and healthcare systems. RECENT FINDINGS:The need to distinguish betw...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Turner PJ,Boyle RJ

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:There is a need to develop a screening tool to assist clinical staff in deciding whether or not a patient in the ICU should be given nutrition support. The purpose of this review is to analyze the recent randomized trials in this context. RECENT FINDINGS:Five trials describe the effect of early suppl...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Kondrup J

更新日期：2014-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this study is to highlight recent research findings that advance our understanding of the relation between iron status and neural functioning. RECENT FINDINGS:Recent findings have helped to answer questions pertaining to the interrelationship of iron and neural functioning in three pri...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Murray-Kolb LE

更新日期：2013-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Both dietary and nondietary factors contribute to iron deficiency, the most common nutritional deficiency worldwide. Identifying dietary factors associated with iron deficiency is challenging due to the number of components in food affecting iron absorption. This review describes recent advances in di...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Beck KL,Heath AL

更新日期：2013-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review focuses upon the biology and metabolism of a trace component in foods called nicotinamide riboside. Nicotinamide riboside is a precursor of nicotinamide adenine dinucleotide (NAD), and is a source of Vitamin B3. Evidence indicates that nicotinamide riboside has unique properties as a Vitam...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Chi Y,Sauve AA

更新日期：2013-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Recently, the US Food and Drug Administration and the European Medicines Agency approved the glucagon-like peptide 2 analogue, teduglutide, for the treatment of short bowel syndrome (SBS), and this review describes the physiological basis for its clinical use. RECENT FINDINGS:By affecting the intesti...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Jeppesen PB

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Fructose malabsorption is associated with gastrointestinal symptoms. This review examines new findings on the physiology, assessment and therapy of fructose malabsorption in functional gastrointestinal disorders. RECENT FINDINGS:Additional GLUT transport mechanisms that regulate fructose absorption m...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Putkonen L,Yao CK,Gibson PR

更新日期：2013-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent conceptual frameworks and empirical findings addressing the role of prenatal stress and stress biology in the context of fetal programming of metabolic function and obesity risk. RECENT FINDINGS:The link between stress exposure and adverse health outcomes is well established. Grow...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Entringer S

更新日期：2013-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Size at birth is critical in determining life expectancy with both small and large neonates at risk of shortened life spans. This review examines the hormonal and nutritional drivers of intrauterine growth with emphasis on the role of foetal hormones as nutritional signals in utero. RECENT FINDINGS:N...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Sferruzzi-Perri AN,Vaughan OR,Forhead AJ,Fowden AL

更新日期：2013-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To understand the impact of microRNA on myogenesis and muscle wasting in order to provide valuable information for clinical investigation. RECENT FINDINGS:Muscle wasting increases the risk of morbidity/mortality in primary muscle diseases, secondary muscle disorders and elderly population. Muscle mas...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Wang XH

更新日期：2013-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Vascular function is recognized as an early and integrative marker of cardiovascular disease. While there is consistent evidence that the quantity of dietary fat has significant effects on vascular function, the differential effects of individual fatty acids is less clear. This review summarizes recen...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Lovegrove JA,Griffin BA

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Randomized controlled trials can be difficult to conduct in critically ill patients and may not always be the most appropriate type of study. Cohort studies can provide valuable information in large complete populations of patients without strict exclusion criteria and without the need for informed co...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Vincent JL,Preiser JC

更新日期：2013-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Malnutrition and polypharmacy increase with age and polymorbidity and their relationship is based on a number of mechanisms. The occurrence of malnutrition in both in-patients and out-patients and its dependence on polymorbidity and age are well known, but the interrelation of polypharmacy and malnutr...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Zadak Z,Hyspler R,Ticha A,Vlcek J

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Oxidative stress plays a central role in the transition from simple steatosis to nonalcoholic steatohepatitis (NASH). An effective therapeutic strategy is to target reduction in oxidative stress in NASH patients. The aim of this review is to discuss the role of oxidative stress in NASH and biological ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Pacana T,Sanyal AJ

更新日期：2012-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The present review aims to address the role of adipose tissue oxygen partial pressure (PO2) in the metabolic and endocrine derangements in conditions characterized by insulin resistance. RECENT FINDINGS:The balance between adipose tissue oxygen supply and its metabolic rate seems to determine adipose...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Goossens GH,Blaak EE

更新日期：2012-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Nonalcoholic fatty liver disease (NAFLD) is the liver epidemic of our time. Diet strongly influences its development and should be a component of any treatment plan. It is crucial to standardize diet recommendations in an evidence-based manner. RECENT FINDINGS:Calorie restriction per se seems benefic...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Carvalhana S,Machado MV,Cortez-Pinto H

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The data indicating that alcohol is an important factor increasing the risk to develop gastrointestinal cancer are consolidating. The purpose of this review is to summarize current evidence. RECENT FINDINGS:Acetaldehyde is the first metabolite of ethanol metabolism and has direct carcinogenic and mut...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Haas SL,Ye W,Löhr JM

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This article aims at reviewing the recent findings that have been made concerning the crosstalk of carbohydrate metabolism with the generation of small, dense low-density lipoprotein (LDL) particles, which are known to be associated with an adverse cardiovascular risk profile. RECENT FINDINGS:Studies...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Gerber PA,Berneis K

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The rapid muscle loss that accompanies varying diseased states (cachexia) is due to an imbalance between muscle protein synthesis (MPS) and muscle protein breakdown In the current review, we will discuss and summarize recent evidence in order to provide practical recommendations on exercise and nutrie...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Breen L,Phillips SM

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent clinical trials have furthered our understanding of the role of probiotic and synbiotic therapy across a variety of diverse diseases including antibiotic-associated diarrhea, Clostridium difficile associated diarrhea, acute pancreatitis, ventilator-associated pneumonia, and sepsis among others....

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Morrow LE,Gogineni V,Malesker MA

更新日期：2012-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Investigations into the regulation of muscle protein synthesis (MPS) are a cornerstone of understanding the control of muscle mass. Rates of MPS are finely tuned according to levels of activity, nutrient availability and health status. For instance, rates of MPS are positively regulated by exercise an...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Phillips BE,Hill DS,Atherton PJ

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The function and use of vitamin D supplementation has become very controversial. This review attempts to provide a balanced perspective with respect to the experimental findings published in the past 18 months. RECENT FINDINGS:The recent contrasts between the Institute of Medicine (IOM) report and th...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Hollis BW

更新日期：2011-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To characterize methods evaluating and to summarize studies linking various serum 25-hydroxyvitamin D [25(OH)D] concentrations with health status. RECENT FINDINGS:Elucidation of the cell-biologic mechanism of vitamin D action, and numerous clinical trials and observational studies relating vitamin D ...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Heaney RP

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the recent work on potential mechanisms underlying a paradoxical positive association between the consumption of non-nutritive sweeteners (NNS) and weight gain. RECENT FINDINGS:Several potential mechanisms, not mutually exclusive, are hypothesized. First, by dissociating sweetness from calo...

journal_title：Current opinion in clinical nutrition and metabolic care

authors： Pepino MY,Bourne C

更新日期：2011-07-01 00:00:00